One of the biggest problem areas for clearance I found for wider tires is where the chain stays fork off the BB. If you can clear that your home free. You want to try to get the wheel as far back in the drop out as you can even if you have to add extra links. One of the most popular tires in between 2.125" and 3" are the Fat Franks at 2.35". If you put these on a regular 2.125 size rim they usually don't give you any trouble. If you buy wheels with larger rims to match the 2.35 tires you start getting tighter on clearance. If you have mutiple bikes you can experiment with tires as some will work differently on different frames. If you happen to have a 24" wheel the 3" tires are very tall for the 24" and they look super HOT!. So, budget may have a bearing on this also. There are also many outfits selling tires of all widths, style, tread - it's like Christmas for tires. If you need links to these places just ask on a post and these guys will direct you to all kinds of goodies. Mostly, HAVE FUN!!!