Back in 1989 I bought a new Schwinn High Sierra that had them, I didn't like them from day one. They were billed as being easier to ride for those with knee issues but I found the exact opposite. They came off the bike after only a few months.
I actually tried them again 20 years later and got the same results.
However, I know many who swear by Biopace rings and actively hunt for them.
They work in theory but I never liked how they felt. I kept getting told that you'll never notice them but they were wrong.
The first change I made to the High Sierra was to only put a round ring on the larger ring, that felt better but you had to be careful when shifting and it led to some ugly scarred up rings so both got changed out for round rings.
I still never liked the bike in general. The index shifters, shorter wheel base, combined with too aggressive OEM tires finally made me sell it.
(I put it back to 100% stock and sold it after less than a year). In that time Schwinn had recalled the frame due to issues with the black chrome. the replacement frame soon had the chrome peeling off, so it got a new frame again. A week after I got it back with the third frame I sold it and pretty much broke even in the end.